St. Louis, MO
Gateway to the West, Gateway to Business Success
Discover the vibrant business community in St. Louis. Connect with local professionals, join networking groups, and grow your business in America's heartland.
Why Do Business in St. Louis?
A strategic location, affordable costs, and collaborative culture make St. Louis ideal for growth
Major Corporate Hub
Home to 9 Fortune 500 companies including Enterprise Holdings, Emerson Electric, and Express Scripts.
Growing Tech Scene
Emerging tech ecosystem with startups in fintech, health tech, and agtech. Lower cost of living attracts entrepreneurs.
Strong Network Culture
Midwest hospitality creates a collaborative business environment. Professionals are genuinely helpful and accessible.
Affordable Business Costs
Competitive office space, lower wages than coasts, and reasonable cost of living. Great for bootstrapped startups.
Strategic Location
Located at the confluence of the Mississippi and Missouri Rivers, St. Louis offers unparalleled access to transportation networks. Within a day's drive of 50% of the US population, the city is a logistics powerhouse. Lambert International Airport provides direct flights to major cities, while Class I rail service and interstate highways create a distribution advantage for businesses.
Key Industries in St. Louis
Diverse economy with strengths across multiple sectors
Healthcare & Life Sciences
BJC Healthcare, Washington University Medical Center
Financial Services
World Wide Technology, Stifel Financial
Manufacturing
Boeing Defense, Anheuser-Busch
Logistics & Transportation
Central US location, Mississippi River port access
Agriculture & AgTech
Bayer Crop Science, Monsanto legacy, strong agtech startups
Professional Services
Law firms, consulting, accounting with national presence
Local Networking Organizations
Connect with these established groups to build your St. Louis business network
Regional chamber serving businesses across the greater St. Louis area with networking events, advocacy, and resources.
Provides $75,000 equity-free grants to startups willing to locate in St. Louis. Great for entrepreneurial networking.
Downtown innovation hub and coworking space hosting tech meetups, startup events, and entrepreneur gatherings.
Multiple BNI chapters throughout the metro area focused on structured referral networking and business growth.
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